Exposure to endocrine disruptors and alterations in mineralized tissues: A Narrative Review

Background: Endocrine Disrupting Chemicals (EDCs) would cause alterations in organs/systems of exposed individuals or their progeny. Objetive: To identify and analyze the main published findings on effects exposure to EDCs teeth, cartilage, bone. Material Methods: Two databases were analyzed: Medline Web Science. Only observational studies analyzing effect mineralized tissues since 2006 included study. Results: 25 articles selected, most them involving pesticides, plasticizers, personal care products, highlighting organochlorine compounds, bisphenols, phthalates, dioxins, parabens, perfluoroalkyls. Thirty-six per cent reported an accumulation teeth bones, while 64% development morphology, mainly at bone level, primarily affecting mineral density size, as well that bones The type observed was related analyzed, it seemed depend variables such age, sex, ethnicity/race, even metabolic status different species analyzed. No evidence associated with cartilage found. Conclusion: environment, work, home, under routes, are capable accumulating bone, particularly latter. It is necessary study agro-industrial areas, especially teeth.